The main side effect was the development of different in strength and duration of Amoxil reactions. In addition, insulin preparations contain a mixture of proinsulin, pancreatic polypeptide and other proteins. Almost all patients after the introduction of insulin after three months, the appearance of antibodies to it in the blood is noted.
An immediate type reaction associated with the release of immunoglobulin E. It develops after 5-8 hours. Appears as local reactions or anaphylaxis. Delayed reaction. Systemic manifestation that occurs after 12-24 hours. Occurs in the form of urticaria, edema or anaphylactic reaction. A local manifestation may be due to improper administration of the drug - a thick needle is injected intradermally, the skin is injured during injection, an unsuccessful place is chosen, excessively chilled insulin is injected.
The formation of heightened sensesVitality occurs in the following ways: Manifestations of Amoxicillin to insulin. Amoxicillin pills to insulin was noted in 20% of patients. With the use of recombinant insulins, the frequency of Amoxil reactions is reduced. With local reactions, the manifestations are usually noticeable an hour after the injection, they are short-lived and quickly disappear without special treatment. Later or delayed local reactions may develop 4 to 24 hours after the injection and persist for a day. Most often, the clinical symptoms of local reactions of hypersensitivity to insulin look like redness of the skin, swelling and itching at the injection site. Skin itching can spread to surrounding tissues.
Systemic manifestations of insulin allergy are rare, manifested by such reactions: Redness of the skin. Urticaria, itchy blisters. Quincke's edema. Anaphylactic shock. Spasm of the bronchi. Polyarthritis or polyarthralgia. Indigestion. Enlarged lymph nodes.
A systemic reaction to insulin preparations occurs if insulin therapy was interrupted for a long time and then resumed. Diagnosis of an allergic reaction to insulin.
Initially, an immunologist or an allergist establishes a connection between the introduction of insulin preparations and the appearance of hypersensitivity to it based on the study of symptoms and an allergic history.